| Keynote Lecture |
| Lifewstyle and allergy/imumunotoxicology |
Kanehisa Morimoto |
Dep. of Hygiene and Preventive Med. Osaka University |
| Special Lecture <1> |
| Chemical allergy： cellular mechanisms and new approaches to hazard and risｋ assessment. |
Ian Kimber |
Zeneca Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire |
| Special Lecture <2> |
| Effects of environmentalchemical substances on human body -- Multiple Chmical Sensitivity (MCS) -- |
S. Ishikawa |
President of The Japanese Society of Clinical Ecology |
| Symposium |
| Stress and brain-immune interaction. |
T. Hori |
Dept. of Physiology, Faculty of Medicine, Kyusｈu University |
| Effects of restraint stress-observation on experiments using mice- |
Jun Kanno |
Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, Department of Pathology and Immunology, Faculty of Medicine, Tokyo Medical and Dental University |
| Effects of sex hormones on human reproductive immune functions. |
S. Hayakawa(1)，M. Karasaki-Suzuki(1)，E. Ohkoshi(2)，J. Oyama(3)，T. Kanaeda(1)，N. Nagai(1)，M. Ishii(1)，F. Chisima(1)，K. Satoh(1) |
Nihon University (1)School of Medicine, (2)(3)School of Pharmacy |
| Ovariectomy induces enhanced production of proinflammatory cytokines from liver, kidney and bone marrow cells. |
Fujio Kayama(1)，Takahiko Yoshida，Keisuke Nakatsuka |
(1)Department of Environmental Health, Jichi Medical School |
| Endocrine disruptors and immune responses. |
Kou Sakabe |
Division of Cellular Biology and Steroid Toxicology, Department of Morphology, Tokai University School of Medicine |
| Workshop |
| Drug-specific immune responses in guinea pigs. |
N. Katsutani |
Drug Safety Research Laboratories, Eisai Co., Ltd. |
| Evaluation of allergic potential of low molecular weight drugs by mouse popliteal lymph node assay. |
K. Shinkai |
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd. |
| The guinea pig maximization test as a test for assessment of antigenicity. |
H. Hattori，F. Yamaguchi |
Drug Safety Research Lab., Daiichi Pharm. Co., Ldt. |
| Delayed type hypersensitivity and local lymph node assay. |
T. Hariya(1)，M. Hatao(2)，M. Shibata(1)，T. Ashikaga(3)，H. Ichikawa(1) |
Shiseido (1)skin biology research laboratories，(2)materials research laboratories，(3)Safety research laboratories |
| The results of surveys about antigenicity studies conducted in the pharmaceutical companies in Japan. |
N. Tsutsui |
Toxicology Laboratory, Yokohama Research Center, Mitsubishi Chemical Corporation |
| General Presentation |
| Cellular and biochemical aspects of immunotoxycity manifestation of organotin compounds. |
Yasuaki Arakawa |
Dept. of Hygiene & Preventive Medicine, Faculty of Health Sciences, The University of Shizuoka |
| Analysis of serum soluble Fas and soluble Fas ligand in patients with siｌicosis. |
A. Tomokuni，T. Otsuki，A. Ueki |
Dept. of Hygiene, Kawasaki Medical School |
| Analysis of mRNA expression in Fas-mediated apoptosis inhibitor genes and caspases in cases with silicosis. |
T. Otsuki，A. Tomokuni，A. Ueki |
Dept. Hygiene, Kawasaki Med. Sch. |
| Investigation of in vitro antigenicity test. |
T. Inoue，I. Horii |
Dept. of Preclinical Science, Nippon Roche Research Center |
| A new method for predictive testing of contact seｎsitizers using human monocyte cell line (THP-1). |
N. Tsutsui，C. Crist，J. Soejima |
Toxicology Laboratory, Yokohama Research Center, Mitsubishi Chemical Corporation |
| Immunological characteristic of mouse popliteal lymph node reｓponse to low-molecular allergenic compounds. |
T. Aida，T. Kimura，N. Ishikawa，K. Shinkai |
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd. |
Establishment of rug-induced and allergic interstitial nephritis model - Do as a new
means of the antigen screening for drugs - |
D. Takahashi et al |
Faculty of Pharmaceutical Sciences, Chiba University |
| Testing for active systemic anaphylactic reactions with NC mice. |
Junko Soejima，Sachiko Mochiduki，Isamu Hosokawa，Naohisa Tsutsui |
Toxicology Laboratory, Yokohama Research Center, Mitsubishi Chemical Corporation |
| An induction of immunogenicity through the oral administration of ovalbumin(OVA). |
H. Akiyama(1)，R. Teshima(2)，R. Narimatsu(1)，Y. Goda(1)，J. Sawada(2)，M. Toyoda(1) |
(1)Div. of Foods，(2)Div. of Biochemistry and Immunochemistry, National Institute of Health Sciences |
| Immunological tests of peripheral blood neutrophils in cynomolgus monkey. |
M. Yokota，R. Watanabe，M. Inoue |
Safety Assessment Laboratory, Chugai Pharmaceutical Co., Ltd. |
| New approach to evaluate the modulation effects of chemicals on immune response to Pneumococcal polysaccharide-Pneumolysin Conjugate antigen- |
T. Kosaka(1)，Y. Takeuchi(1)，K.Maita(1)，C. J. Lee(2) |
(1)Toxicology Division, The Institute of Environmental Toxicology， (2)Center for Biologics Evaluation and Research/FDA |
| Evaluation of immunotoxicity tests using dexamethasone and cyclosporin A-Ⅳ |
M. Inoue，K. Mochizuki，Y. Ito，J. Yoshida，T. Arika |
Kaken Pharmaceutical Co., Ltd. |
| Induction of tight skin in mice by arsenic exposure: role of GM-CSF and TGFα. |
T. Yoshida(1)，H. Aikawa(1)，K. Sakabe(1)，F. Kayama(2)，H. Yamauchi(3)，W. Fujimoto(4) |
(1)Tokai Univ. Sch. of Med., (2)Jichhii Univ. Sch. of Med.，(3)St. Marianna Univ. Sch. of Med.，(4)Okayama Univ. Sch. of Med. |
| Effects of environmental pollutants on the release of proinflammatory cytokines from normal human dermal keratinocyte. |
H. Ushio，H. Fujimaki |
Environmental Health Science Div. National Institute for Environmental Studies |
| Role of diesel exhaust particles in oral immunization. |
S. Yoshino(1)，H. Hayashi(2)，Y. Mori(3)，M. Ohsawa(4)，M. Sagai(5) |
(1)Dept. of Microbiology, Saga Medical School，(2)Dept. of Clinical Toxicology and Metabolism，(3)Dept. of Immunology and Microbiology, Faculty of Pharmaceutical Sciences, Health Sciences Uniｖersity of Hokkaido，(4)Dept. of Environmental Toxicology, Faculty of Pharmaceutical Sciences，Teikyo University，(5)Research Team for Health Effects of AirPolutions, Nat. Inst. for Environmental Studies |
| Detecｔion of intracellular cytokines of mouse lymphocytes activated in vitro. -Analysis using Flow Cytometer(FCM)- |
Y. Takeuchi，T. Kosaka，T. Harada，K. Maita， |
Toxicology Division， The Institute of Environmental Toxicology. |
| Effects of ovariectomy on specific antibody responses in rats. |
M. Nagata，M. Hino，K. Nakamura |
Developmental Research Laboratories, Shionogi & Co., Ltd. |
| Evaluation of specific IgE to Japanese cedar pollen in sera of humans with pollinosis by a human mast cell histamine-releasing test. |
A Imai(1)，M. Toriyama(1)，T. Imai(2)，M. Yanagida(1) |
(1)Pharmaceutical Development Laboratory, Kirin Brewery Co., Ltd., (2)Department of otorhinolaryngology, The Jikei Uniｖersity School of Medicine |
| Allergic rhinitis and serum immunological study in workers exposed to methyltetra- hydrophthalic anhydride in 2 condenser manufacturing factories. |
K. Yamaguchi(1)，K. Yokota(1)，Y. Jyoyama(1)，Y. Fujiki(1)，T. Takeshita(2)，K. Morimoto |
(1)Matsushita Science Center of Industrial Hygiene，(2)Dep. of Hygiene and Preventive Med. Osaka University |
