| Special Lecture <1> |
| Immunopaahological aspects of chemical and drug toxicities and risk assessment |
Joseph G. Vos |
National Institute of Public Health and the Environment (RIVM) |
| Special Lecture <2> |
| Mucosal Immune System and Immunotoxicology. |
H. Nagura |
Department of Pathology, Tohoku University School of Medicine. |
| Special Lecture <3> |
| Safety evaluation of biotechnology products, including immunotoxicityA |
Joy A. Cavagnaro |
Center for Biologics Evaluation and Research U. S. Food and Drug Administration |
| Mini-symposium |
| Cytokine Production by Human Airway Eoithelial Cells - Effects of Air - Pollutants. |
Takayuki Ohtoshi |
Dept. of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo |
| Risk assessment of man - made mineral fibers using RT- PCR |
T.Tsuda(1),Y.Morimoto(1), H.Nakamura(1), H. Hori(2),H.Yamato(1), S. Ishimatsu(2), T.Oyabu(1), AFujino(1), J.Nambu(2), T.Higashi(1), I.Tanaka(1) |
(1)Institute of Industrial Ecological Sciences, (2)University of Occupational Environmental Health, Japan. |
| Workshop |
| Collaborative Immunotoxicological Study by Fourteen - day Oral Administration of Cyclophoshamide - Organ weight and Histo - pathology - |
Y. Okamoto(1), Y.Kawachi(2), S. Kono(3), A. Ozaki(4), K. Amano(5), R. Suzuki(6), D.Nakatsuka(7), K. Taguchi(7), K. Nagami(8), K. Yuasa(9), D. Nagai(10), K. Nakamura(11) |
(1)Toray, (2)Taiho, (3)Bristol - Myers Squibb, (4), Otsuka, (5)Kowa, (6), Nippon Glaxo, (7)Nippon Hoechst Marion Roussel, (8)Banyu, (9)Tanabe, (10)Nihon Kayaku, (11)Shionogi |
| Collaborative Immunotoxicological Study by Fourteen - day Oral Administration of Cyclophosphamide - Spleen Cellularity and Flow Cytometry - |
K. Nakamura(1), Y. Kouchi(2), A. Ozaki(3), H. Tsutsui(4), R. Suzuki(5), S. Kawano(6), Y. Amano(7), D. Nakatsuka(8),K. Nagami(9), H. Yuasa(10), D.Nagai(11) |
(1)Shionogi, (2)Taiho, (3)Otsuka, (4)Mitsubishi Chemical, (5)Nippon Glaxo, (6)Bristol - Myers Squibb, (7)Kowa, (8)Nippon Hoechst Marion Roussel, (9)Banyu, (10)Tanabe, (11)Nippon Kayaku |
| Collaborative Immunotoxicological Study by Fourteen - day Oral Administration of Cyclophos - phamide -Evaluation of Humoral Immune Response by Enzyme - linked Immunosorbent Assay - |
S. Kawano(1), A. Ozaki(2), D. Nakatsuka(3), K. Nakamura(4), T.Masuda(5), D. Nagai(6), M. Hayakawa(7) |
(1)Bristol - Myers Squibb, (2)Otsuka Pharmaceutical,(3)Nippon Hoechst Marion Roussel,(4)Shionogi,(5)Lederle(Japan),(6)Nippon Kayaku,(7)Mitsui Pharmaceutical |
| Collaborative Immunotoxicological Study by Fourteen - day Oral Administration of Cyclophosphamide - Natural Killer Activity - |
N. Tsutsui(1), K. Nakamura(2), Y. Kouchi(3), K. Nagami(4) |
(1)Mitsubishi Chemical, (2)Shionogi, (3)Taiho Pharmaceutical, (4)Banyu |
| General Presentation |
| Quantitative Evaluation of Passive Cutaneous Anaphylaxis (PCA) Using A Hand - held Spectrophotometer. |
H. Akiyama(1), R. Teshima(2), R. Akasaka(2), Y. Goda(1), J. Sawada(2),M. Toyoda. |
(1)Div. of Foods (2)Div. of Biochemistry and Immunochemistry, National Institute of Health Sciences. |
| A prediction of chemical - induced immunogenicity using popliteal lymph node assay. |
Y. Kouchi, Y. Maeda, A. Ohuchida. |
Drug Safety ResearchLaboratory, Taiho |
| Studies on Isolation of Carrier Protein in Primary Cultured Rat Hepatocytes. |
A.Toda(1), Y. Hisanari(1), Y. Masuda(1), H. Shigematsu(1), R.Eyanagi(2) |
(1)Dept. of Hygienic Chemistry, Daiichi College of Pharmaceutical Sciences. (2)Daiichi University - College of Technology. |
| Effects of low concentration of formaldehyde on experimentally induced type I and W allergy in mice. |
T. Yoshida(1), T. Hagino(1) F. Kayama(2), |
(1) Dept. of Environmental Health,Tokai University School of MedicineA(2)Dept. of Environmental Health, Jichi Medical University. |
| The increase of histamine rlease from rat mast cells with several pesticides. |
K. Ikeda, M. Taguchi, T. Sato, H. Nagase, H. Kito, M. Niikawa. |
Dept. of Public Health, Gifu Phamaceutical University |
| Effects of some antioxidants on calcium signals, degranulation and LTC4 release of RBL-2H3 cells. |
R. Akasaka(1), R. Teshima(1), S. Kitajima(2), J. Momma(2), T. Inoue(2), J. Sawada(2) |
(1)Div. of Biochemistry and Immunochemistry (2)Div. of Toxicology, National Institute of Health Sciences |
| Induction of oral immunity and blockade of oral tolerance by diesel exhaust particles. |
S.Yoshino(1),M.Sagai(2) |
(1)Dept. of Microbiology, Saga Medical School (2)Research Team for Health Effects of Air Polutions, Nat. Inst. for Environmental Studies |
| Immunotoxicity on the Humoral Immune Response to Thymus- independent Antigen. |
M. Nagata, S. Kimura, A. Watanabe, M. Takeuchi, K. Nakamura. |
Developmental Research Laboratories, Shionogi & Co., Ltd. |
| Immunotoxicity tests in rats, Comparison of rat strain F344 with SD. |
J. Kai(1), M. Shimada(2), H. Imade(1), J. Sonoda(1), Y. Sugihara(1), T. Mikami(1) |
(1)Dept. of Drug Safety Research, Eisai Co., Lid. (2)Kawashima Co., Lid. |
| Morphological Evaluation of Cell Kinetics in the Lymphoid Organs Using Labeling Indices of BrdU and TUNEL. |
K. Toyoda, T. Shoda, C. Uneyama, K. Takada, M. Takahashi. |
Division of Pathology, National Institute of Health Sciences. |
| Esatblishment of Granulocyte Colony Formation Assay using SD Rat Bone Marrow Cells. |
K. Matsumura, A. Ozaki, |
Tokushima Resarch Institute, Otsuka Pharmaceutical Co., Ltd. |
| Evalution of immunotoxicity tests using Dex. and CysA. |
M. Inoue, R. Nagatahira, K. Motizuki, Y. Ito, J. Yoshida, K. Saitoh |
Safety Research Laboratories Kaken Pharmaceutical Co., Ltd. |
| Effects of Interleukin - 12 on Normal and Tumor - bearing Mice. |
T. Inoue, K. Shimura, H. Suzuki, I. Horii. |
Dept. Toxicology and Pathology, Nippon Roche Research Center. |
| Immunological insignificance of fenitrothion in mice and rats. |
T. Kunimatsu, Y. Kamitat, N. Isobe, Y. Okuno, H. Kawasaki. |
Sumitomo Chemical Co., Ltd., Environmental Health Science Laboratory. |
| Evaluation of In Vitro Toxicity of 50 MEIC Compounds on Human Natural Killer Cell Function. |
Y. Kobayashi |
Lab. Of Molecular Immunology, Faculty of Science, Toho University. |
| Effects of ethanol and acetaldehyde on Natural killer cell activity. |
C. Inoue, T. Takeuchi, T. Takeshita, K. Morimoto. |
Department of Hygiene and Preventive Medicine, Osaka University School of Medicine |
| Cadmium Induces Apoptosis in Immune System. |
M. Ishido, H. Fujimaki. |
National Insititute for Environmental Studies. |
| Role of Proinflammatory Cytokines in Rat Experimental Hepatitis Induced by Endotoxins in vitro. |
K. Ueno, H. Shinohara, A. Kobayashi, K. Chiba. |
Lab. of Biochem. Pharmacol. & Biotoxicol., Faculty of Pharmaceutical Sciences, Chiba University |
| Application of precision - cut kidney slice culture as a model of kidney immunotoxicological evaluation. |
F. Kayama(1), K. Nakatsuka(1), T. Yoshida(2), |
(1)Dept. Environ. Health, Jichi Med.School., (2)Dept. Environ. Health, Tokai Univ. Sch. Med. |
