| Invited Plenary Lecture |
| The Histamine H4 Receptor and Immune Function |
Robin L. Thurmond |
Johnson & Johnson Pharmaceutical Research & Development, L.L.C., USA |
| Special Lecture |
| Environmental contaminants and children’s health |
Chisato Mori (1, 2) |
(1) Department of Bioenvironmental Medicine, Graduate School Medicine, Chiba University， (2) Center of Preventive Medical Science, Chiba University |
| Master’s Lecture |
| Genetic risk factors related to severe cutaneous adverse reactions |
Nahoko Kaniwa |
Division of Medicinal Safety Science, National Institute of Health Sciences |
| Awards Lectures |
| JSIT AWARD for Distinguished Contribution |
| Regulation of drug- and stress esponsive-enzyme expressions based on immunological mechanisms |
Takemi Yoshida ( (1, 2) |
(1) Council on Pharmacists Credentials,Tokyo, Japan (2) Showa University, Tokyo, Japan |
| JSIT RESEARCH AWARD |
| Immunological bioassay for infant food allergy |
Ryosuke Nakamura |
Div. Novel Foods Immunochem., Natl. Inst. Health Sci. |
| Symposium “Food Allergy- From in vitro prediction test to clinical test –“ |
| Food Allergy, intestinal immunity and oral tolerance |
Hiroshi Ohno |
Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Yokohama, Japan |
| Maintenance of IL-4 production by CD4+T cells in mesenteric lymph nodes is indispensable in inducing T cell-dependent food allergic enteropathy |
Haruyo Nakajima-Adachi |
Department of Applied Biological Chemistry, Graduate School of Agriculture and Life Science, The University of Tokyo, Tokyo, Japan |
| Development of new diagnostic method for cross-reactivity between food allergens |
Yasuto Kondo (1), Kazuo Ogura (1), Norihiko Naruse (1), Noriko Hirata (1), Satiko Suzuki (1), Hitoshi Ando (1), Kinichi Tanaka (2), Yoichi Nakajima (2), Chisato Inuo (2), Ikuya Tusge (2), Atsuo Urisu (1) |
(1) Fujita Health University, The second Teaching Hospital, Nagoya, Japan (2) Fujita Health University, Toyoake, Japan |
| Animal Models to Assess Protein Allergenicity: State of the Science |
Gregory S. Ladics |
DuPont Agricultural Biotechnology, Wilmington, DE, USA. |
| Workshop “Methods of Assessment for Developmental Immunotoxicity” |
| Developmental Immunotoxicology: ‘State-of-the-Science’ |
Gregory S. Ladics |
DuPont Agricultural Biotechnology, Wilmington, DE, USA |
| A new assay system for evaluation of developmental immunotoxicity of chemical compounds using RSV infection to offspring mice |
Wataru Watanabe |
)Department of Microbiology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Nobeoka, Japan |
| Studies on the effects of toluene exposure on developing immune system |
Win-Shwe Tin-Tin (1)，Kunugita Naoki (2)，Yoshida Yasuhiro (3)，Fujimaki Hidekazu (4) |
National Institute for Environmental Studies (1) National Institute of Public Health (2) University of Occupational and Environmental Health, Japan (3) National Institute for Environmental Studies (4) |
| The effect of perinatal/infant Methoxychlor exposure in rat immune system |
Koichi Hayashi，Tadashi Kosaka |
Institute of Environmental Toxicology, Ibaraki, Japan |
| Oral Presentations |
| Fetotoxicity of nanomaterials for the development of safe nanomaterials |
Yasuo Yoshioka (1,2,3)，Kohei Yamashita (1)，Kazuma Higashisaka (1)，Yuki Morishita (1)，Kazuya Nagano (3)，Yasuhiro Abe (3)，Haruhiko Kamada (2,3)，Shin-ichi Tsunoda (2,3)，Hiromi Nabeshi (1)，Itaru Yanagihara (4)，Shigeru Saito5，Norio Itoh (1)，Tomoaki Yoshikawa (1)，Yasuo Tsutsumi (1,2,3) |
(1) Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan (2) The Center for Advanced Medical Engineering and Informatics, Osaka University, Osaka, Japan (3) Laboratory of Biopharmaceutical Research, National Institute of Biomedical Innovation, Osaka, Japan (4) Department of Developmental Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan 5)Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan |
| Particulates induce macrophages to produce lipid mediators via the Syk activation |
Etsushi Kuroda (1)，Yasuo Morimoro (2) |
(1) Department of Immunology and Parasitology, University of Occupational and Environmental Health, Japan (2) Department of Occupational Pneumology, University of Occupational and Environmental Health, Japan |
| The relationship between low IL-12, IFN-γ and IL-17A levels and low NKp46 on NK cells in the culture of PBMCs upon asbestos exposure |
Yasumitsu Nishimura (1)，Naoko Kumagai (1)，Megumi Maeda (2)，Hidenori Matsuzaki (1)，Suni Lee (1)，Takemi Otsuki (1) |
(1) Department of Hygiene, Kawasaki Medical School, Kurashiki, Japan (2) Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan |
| The effects of asbestos exposure on maturation and maintenance of memory CTL induced by mixed lymphocyte reactions |
)Naoko Kumagai (1)，Yasumitsu Nishimura (1)，Megumi Maeda (2)，Hiroaki Hayashi (1)，Hidenori Matsuzaki (1)，Suni Lee (1)，Takemi Otsuki (1) |
(1) Department of Hygiene, Kawasaki Medical School, Okayama, Japan (2) Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan |
| Effects of isoflavones on RORγt-dependent IL-17 gene expression |
Hiroyuki Kojima (1)，Ryuta Muromoto (2)，Miki Takahashi (2)，Shinji Takeuchi (1)，Tadashi Matsuda (2) |
(1) Hokkaido Institute of Public Health, Sapporo, Japan (2) Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan |
| A novel animal model of pruritus induced by successive application of glucocorticoid to mouse skin |
Katsunori Yamaura，Ryosuke Doi，Eriko Suwa，Koichi Ueno |
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan |
| Possibility of immunotoxicity evaluation by ocular instillation in rats |
Yoshihiro Oshita, Mitsunori Meda, Kouichi Kawazu |
Non-clinical Research Group, Nara Research and Development Center, Santen Pharmaceutical CO.,Ltd. |
| The role of neutrophil infiltration in Methotrexate (MTX)-induced intestinal barrier dysfunction |
Shuichi Sekine, Chiaki Asada, Tomoko Maeda, Naoko Kakigawa, Toshiharu Horie |
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University |
| Myelotoxicity of indium oxide (2nd report) - chromosomal aberration- |
Yuichi Miyakoshi, Toshikazu Koiwai, Hiroyuki Yanagizawa |
Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Tokyo, Japan |
| Mechanism of ziram-induced apoptosis in human T lymphocytes |
Qing Li，Maiko Kobayashi，Tomoyuki Kawada |
Department of Hygiene and Public Health, Nippon Medical School |
| Skin sensitization study by a new qualitative structure-toxicity relationships (QSTR) approach: K-step Yard sampling (KY) methods |
Kazuhiro Sato (1)，Yukinori Kusaka (1)，Kohtaro Yuta (2) |
(1) Department of Environmental Health, School of Medicine, University of Fukui, Fukui, Japan， (2) In Silico Data Ltd., Chiba, Japan |
| Examination of Flowcytometry method for measuring NK activity |
Satoshi Saitoh，Kyouko Harita，Maiko Fukushima，Youko Kakizaki，Sumako Iwanaga，Kazuhiro Abe，Kouji Nakayama |
Molecular Genetic Research and Analysis Department,Advanced Medical Science Research Center,Mitsubishi Chemical Medience Corporation,Tokyo,Japan |
| Current Situation of Histopathological Examination on the Immune System Organs in Standard Toxicity Studies |
Yamato Ogino, Akio Kobayashi, Shigeo Kawano, Kazuhiko Taguchi, Takashi Nagayama, Keiko Motoyama, Kazuhiro Hosoi, Shigeru Hisada, Kazuichi Nakamura |
Non-Clinical Evaluation Subcommittee, Drug Evaluation Committee, Japan Pharmaceutical Manufacturers Association |
| Changes of components in breast milk by stress of child care and the effects of thalassotherapy on them |
Kuniaki Takagi，Yukina Ichiki，Masakuni Degawa |
School of Pharmaceutical Science, University of Shizuoka, Shizuoka, Japan |
| Poster Presentations |
| Chronic exposure to chrysotile asbestos induces IL-17 production in cultured human peripheral CD4 T cells in vitro |
Megumi Maeda (1), (2)，Naoko Kumagai (2)，Hidenori Matsuzaki (2)，Suni Lee (2)，Yasumitsu Nishimura (2)，Takemi Otsuki (2) |
(1) Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University, Japan (2) Department of Hygiene, Kawasaki Medical School |
| Effect of Asbestos on forkhead transcription factor FoxO1 |
Hidenori Matsuzaki (1)，Megumi Maeda (2)，Suni Lee (1)，Naoko Kumagai (1)，Yasumitsu Nishimura (1)，Takemi Otsuki (1) |
(1) Department of Hygiene, Kawasaki Medical School, Kurashiki, Japan (2) Department of Biofunctional Chemistry, Graduate School of Natural Science an d Technology, Okayama University, Japan |
| The enhancement of CD8 positive cell proliferation caused by trichloroethylene |
Ryo Kobayashi，Tsuyoshi Nakanishi，Hisamitsu Nagase |
Gifu Pharmaceutical University, Gifu, Japan |
| The effects of fluoride on mRNA expressions of cytokines in the splenic macrophages in ICGN mice and ICR mice via drinking water |
Takamasa Kido (1,2)，Masashi Tsunoda (2)，Chiemi Sugaya (2)，Ryutaro Ikeuchi (1,2)，Yukio Kodama (4)，Ryouko Konishi (4)，Kazuyoshi Itai (3)，Yoshiharu Aizawa (2) |
(1) Graduate School of Medical Sciences, Kiasato University of Sagamihara, Kanagawa Japan (2) Preventive Medicine and Public Health, Kiasato University School of Medicine (3) Preventive Medicine and Public Health, Iwate Medecal University (4) National Institute of Health Sciences |
| Prior oral exposure to environmental immunosuppressive agents aggravates mite allergen-induced atopic dermatitis-like immunoreaction |
Tomoki Fukuyama，Yukari Tajima，Koichi Hayashi，Hideo Ueda，Tadashi Kosaka |
)Toxicology Division, The Institute of Environmental Toxicology, Ibaraki, Japan |
| The immunobiological effects of negatively-charged air particle dominant indoor air circumstance |
Takemi Otsuki (1)，Kazuaki Takahashi (2)，Kouki Manabe (3)，Muneo Kotani (3)，Megumi Maeda (4)，Naoko Kumagai (1)，Hidenori Matsuzaki (1)，Suni Lee (1)，Yasumitsu Nishimura (1) |
(1) Dept. Hyg., Kawasaki Med. Sch., Kurashiki, Japan (2) Comprehensive Housing R&D Inst., Sekisui House, Ltd.,Kizugawa, Japan (3) Dept. Environ. Enhancement, Sekisui House, Ltd., Osaka, Japan (4) Div. Bioscience, Dept. Biofunct. Chem., Grad. Sch. Nat. Sci. Technol., Okayama Univ., Okayama, Japan |
| The effects of TBT on the productions of cytokines by splenocytes from F1 rats by the exposure from fetus to developing stages |
Masashi Tsunoda (1)，Takamasa Kido (1,2)，Ryutaro Ikeuchi (1,2)，Chiemi Sugaya (1)，Hiroshi Katagiri (3)，Yoshiharu Aizawa (1) |
(1) Department of Preventive Medicine, Kitasato University School of Medicine, Sagamihara, Japan (2) Kitasato University Graduate School of Medical Sciences, Sagamihara, Japan (3) Department of Public Health, Kitasato University School of Allied Health Sciences, Sagamihara, Japan |
| Mechanism of the inhibition of the oral sensitization by β-carotene intake |
Hideki Matsuoka (1)，Hiroshi Akiyama (1)，Kozue Sakata (1)，Rika Nakamura (1)，Shingo Takahashi (2)，Koichi Aizawa (2)，Takahiro Inakuma (2)，Mamoru Tostuka (3)，Reiko Teshima (1) |
(1) National Institute of Health Sciences, Tokyo, Japan (2) Research Institute, Kagome Co., Ltd., Nasushiobara-shi, Japan (3) Department of Applied Biological Chemistry , The University of Tokyo, Tokyo, Japan |
| A New In Vitro Assay System for Assessment of Food Allergenicity : (3) Coupling with In Vitro Protein Digestion Process |
Terumi Katori (1), Tomoko Shindo (1), Motoyasu Ohsawa (1), Kohichi Kojima (1), Reiko Teshima (2) |
(1) Hatano Research Institute, Food and Drug Safety Center, Hadano, Japan (2) National Institute of Health Sciences, Tokyo, Japan |
| Murine Oral Food Allergy Model: Alteration of Productive IgA Contents in Intestine |
Tomoko Shindo (1), Terumi Katori (1), Yukiko Kanazawa (2), Kohichi Kojima (1), Reiko Teshima (3) |
(1) Hatano Research Institute, Food and Drug Safety Center, Hadano, (2) Pharmaceuticals and Medical Devices Agency, Tokyo, (3) National Institute of Health Sciences, Tokyo, Japan |
| 学生・若手セッション |
| Effects of histamine H (4) receptor antagonist JNJ7777 (1) (2)0 on the mouse model of atopic dermatitis |
Eriko Suwa, Katsunori Yamaura and Koichi Ueno |
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University |
| Effect of Acrolein on Macrophages |
Kenta Watanabe (1), Itsuko Ishii (1), Yuki Nakazato (1), Kazuei Igarashi (1), (3), Mitsukazu Kitada (2) |
(1))Graduate School of Pharmaceutical Sciences, Chiba University, (2))Division of pharmacy, Chiba University Hospital, (3))Amine Pharma Research Institute |
| Allergenicity test of Arabidopsis DREB (1)A-Transgenic Potato Using Immunoproteomic and (2)D-DIGE Analysis |
Rika Nakamura (1)，Rie Satoh (1), (2)，Ryosuke Nakamura (1)，Takayoshi Shimazaki (3)，Mie Kasuga (4)，Kazuko Shinozaki (4)，Akira Kikuchi (3)，Kazuo Watanabe (3)，Reiko Teshima (1) |
(1))Division of Novel Foods and Immunochemistry, National Institute of Health Sciences, Tokyo, Japan (2))National Food Research Institute, Tsukuba, Japan (3))Gene Research Center, Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan (4)) Biological Resources Division, Japan International Research Center for Agricultural Sciences (JIRCAS), Tsukuba, Japan |
| Allergenicity of heat-processed egg white revealed by cell-based assay |
Ayano Ishiwatari (1), (2)，Ryosuke Nakamura (1)，Masakazu Higuchi (1)，Yoshimi Uchida (1)，Rika Nakamura (1)，Hiroshi Kawakami (2)，Atsuo Urisu (3)，Reiko Teshima (1) |
(1))The Division of Novel Foods and Immunochemistry, National Institute of Health Sciences, Tokyo, Japan (2))Graduate School of Food Science, Kyoritsu Women's University, Tokyo, Japan (3))Department Pediatrics, The Second Teaching Hospital of Fujita Health University, Aichi, Japan |
| Effects of exposure of human NK cells to arsenite on gene expression end cytotoxic activit |
Hiromasa Tsuyama，Daigo Sumi，Tomoko Ogawa，Seiichiro Himeno |
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan |
| Enhancing effects of oral-administered oxidized olive oil on mouse skin allergy |
Hirofumi Ogino (1)，Kei Okayama (1)，Miho Kitayama (1)，Iku Yabuta (1)，Syogo Asakura (1)，Yusuke KikuchiI (1)，Chisa Betto (1)，Koichi Murano (1)，Ryo Yonemitu (1)，Fumitoshi Sakazaki (1)，Tomohiro Arakawa (1)，Tomofumi Okuno (1)，Katsuhiko Nakamuro (2)，Hitoshi Ueno (1) |
(1) Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan (2) Faculty of Science & Engineering, Setsunan University, Neyagawa, Osaka, Japan |
| Luncheon Seminars |
| Biomarkers of inflammation |
Simon Lavallée |
Principal Scientist，Charles River Laboratories Preclinical Services Montreal Inc, Canada |
| Immunogenicity of biotherapeutics; contributing factors, impact and mitigation |
Christopher Kirton |
Huntingdon Life Sciences Ltd., UK |
