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The 17th Annual Meeting of JSIT |
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| Invited Plenary Lecture |
| Mast cells and their regulation: Allergy, but so much more – Innate to adaptive immunity” |
A. Dean Befus, Tae Chul Moon, Yokananth Sekar, Chris St. Laurent, Tsuyoshi Yoshimura, Candy Marcet, Shinji Takeuchi, Katherine Morris. |
Pulmonary Research Group, School of Internal Medicine, University of Alberta, Canada |
| Special Lecture |
| Molecular mechanisms underlying pathogen sensing in the innate immune system |
Kensuke Miyake |
The Institute of Medical Science, The University of Tokyo |
| Master’s Lecture |
| Allergenicity testing: current and future issues |
Jun-ichi Sawada |
Pharmaceuticals and Medical Devices Agency, Tokyo, Japan |
| Symposium "Immunotoxicity and chemical susceptibility" |
| Influenza viral disease: Dexamethasone and the role of age and genetics on viral disease |
Gary R. Burleson |
BRT-Burleson Research Technologies, Inc, USA |
| Responses of macrophages against oxidative stress- roles of transcription factor Nrf2 and the induced proteins |
Tetsuro Ishii, Toru Yanagawa, Eiji Warabi |
Majors of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba |
| Effects of volatile organic compounds (VOCs) exposure on immunotoxicity in mice |
Naoki Kunugita (1), Yasuhiro Yoshida (2), Win Shwe Tin Tin (3), Keiichi Arashidani (2), Hidekazu Fujimaki (3) |
(1) Department of Environmental Health, National Institute of Public Health, Wako, Japan, (2) University of Occupational and Environmental Health, Kitakyushu, Japan, (3) Research Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Japan |
| Yellow sand and allergy |
Takamichi Ichinose (1), Masataka Nishikawa (2), Hirohisa Takano (3) |
(1) Department of Health Sciences, Oita University of Nursing and Health Sciences, Oita, Japan, (2) Laboratory of Intellectual Fundamentals for Environmental Studies, National Institute for Environmental Studies, Tsukuba, Japan, (3) Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan |
| Effect of chemicals like brominated flame retardants (BFRs) on the development of the immune system in rodents |
Reiko Teshima, Ryosuke Nakamura |
The Division of Novel Foods and Immunochemistry, National Institute of Health Sciences |
| Workshop “The latest move in the immunotoxicity studies: in silico, in vitro and in vivo” |
| In silico prediction of immunogenicity: sense and non-sense |
Philippe Stas |
Applied Protein Services, Lonza Biologics. |
| Current situation of in vitro testings on skin sensitisation assay |
Hajime Kojima |
Japanese Center for the Validation of Alternative Methods, National Institut e of Health Sciences |
| The inter-laboratory KLH-TDAR assay validation study (Study I ) – investigation for the experimental conditions – |
Kanako Mori (1), Yasuhide Kouchi (2), Ai Hashimoto (3), Hideki Harada (4), Ryota Kawai (5) |
(1) Development Research Center, Takeda Pharmaceutical Company Limited, (2) Toxicology Lab., Tokushima Research Center, Taiho Pharmaceutical Co., Ltd., (3) Discovery Technology Laboratories, Minase Research Institute, Ono Pharmaceutical Co. Ltd., (4) Safety Assessment Department, Non-clinical Research Center, Drug Development Service Segment, Mitsubishi Chemical Medience Corporation, (5) Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd. |
| The inter-laboratory KLH-TDAR assay validation study II– investigation using an immunosuppressive agent – |
yota Kawai (1), Yuko Nagayama (2), Kanako Mori (3), Yasuhide Kouchi (4) |
(1) Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., (2) Tsukuba, Drug Safety Japan, Eisai Co., Ltd., (3) Development Research Center, Takeda Pharmaceutical Company Limited, (4) Toxicology Lab., Tokushima Research Center, Taiho Pharmaceutical Co., Ltd. |
| Oral Presentations |
| Particulates activate innate immune systems and regulate type 2 immunity |
Etsushi Kuroda (1), Yasuo Morimoto (2) |
(1) Department of Immunology and Parasitology, University of Occupational and Environmental Health, (2) Department of Occupational Pneumology, University of Occupational and Environmental Health |
| Safety assessment of nanomaterials: inflammatory responses of nanosilica with different sizes and surface properties |
Yasuo Yoshioka (1,2,3), Tomohiro Morishige (3), Hiroshi Inakura (3), Tomoaki Yoshikawa (2,4), Shin-ichi Tsunoda (1,2,5), Yohei Mukai (3), Naoki Okada (3), Shinsaku Nakagawa (1,3), Yasuo Tsutsumi (1,2,4) |
(1) The Center for Advanced Medical Engineering and Informatics, Osaka University, Osaka, Japan, (2) Laboratory of Biopharmaceutical Research, National Institute of Biomedical Innovation, Osaka, Japan, (3) Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan, (4) Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan, (5) Department of Biomedical Innovation, Graduate school of Pharmaceutical Sciences, Osaka University, Osaka, Japan |
| Functional analysis of peripheral blood CD8+ cells from people positive for pleural plaque |
Naoko Kumagai, Yasumitsu Nishimura, Megumi Maeda, Hiroaki Hayashi, Takemi Otsuki |
Department of Hygiene, Kawasaki Medical School, Kurashiki, Japan |
| Analysis of Foxp3 expression and DNA methylation in MT-2 cells exposed to asbestos |
Megumi Maeda (1), Hiroaki Hayashi (1), Yasumitsu Nishimura (1), Naoko Kumagai (1), Yoshie Miura (2), Takemi Otsuki (1) |
(1) Department of Hygiene, Kawasaki Medical School, Okayama, Japan, (2) Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan |
| Pulmonary toxicity induced by dispersed MWCNT using animal studies |
Yasuo Morimoto (1), Masami Hirohashi (1), Akira Ogami (1), Takako Oyabu (1), Toshihiko Myojo (1), Motoi Todoroki (1), Makoto Yamamoto (1), Masayoshi Hashiba (1), Yohei Mizuguchi (1), Byeong Woo Lee (1), Etsushi Kuroda (2), Manabu Shimada (3), Wang Wei-Ning (3), Kazuhiro Yamamoto (4), Katsuhide Fujita (4), Shigehisa Endoh (4), Kunio Uchida (4), Norihiro Kobayashi (4), Junko Nakanishi (4), Isamu Tanaka (1) |
(1) IIES, University of Occupational and Environmental Health Japan, Kitakyushu, Japan, (2) Dept of Immunology, School of Medicine, University of Occupational and Environmental Health Japan. Kitakyushu, Japan, (3) Hiroshima University, Hiroshima, Japan, (4) National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan |
| Altered production of cytokines and decreased monocyte-lineage cells in the relation with decreased NKp46 on NK cells upon exposure to asbestos |
Yasumitsu Nishimura, Naoko Kumagai, Megumi Maeda, Hiroaki Hayashi, Takemi Otsuki |
Department of Hygiene, Kawasaki Medical School, Kurashiki, Japan |
| Effects of brominated flame retardants on mouse immune cells |
Eiko Koike, Rie Yanagisawa, Hirohisa Takano |
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan |
| Ziram induces apoptosis and necrosis in human immune cells |
Qing Li, Maiko Kobayashi, Tomoyuki Kawada |
Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan |
| Inhibitory effects of pesticides on IL-17 production via retinoid-related orphan receptor |
Hiroyuki Kojima (1), Shinji Takeuchi (1), Miki Takahashi (2), Ryuta Muromoto (2) |
(1) Hokkaido Institute of Public Health, Sapporo, Japan , (2) Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan |
| In vitro T cell-dependent antibody response assay using mouse splenocytes |
Kiyoshi Kushima, Shogo Matsumura, Akihiko Hisatomi, Michio Fujiwara, Jiro Seki |
Drug Safety Research Labs., Astellas Pharma Inc., Osaka, Japan |
| Analysis of human lymphocyte chemotaxis by TAXIScan method |
Akira Yamauchi (1), Futoshi Kuribayashi (1), Shiro Kanegasaki (2) |
(1) The Department of Biochemistry, Kawasaki Medical School, Kurashiki, Japan , (2) The Central Laboratory, ECI, Inc. |
| Developement of the method for chemical risk assessment based on human leukocytes chemotaxis |
Tomoko Tsuchiya, Minoru Ono, Shiro Kanegasaki |
Department of Research, ECI, Inc., Tokyo, Japan |
| Contamination by endotoxin masks the positive immunogenic reaction in helper T-cell proliferation assay |
Marie Hayakawa, Chiyomi Kubo, Yoshika Iwata, Shunsuke Itou, Toshiko Hara, Akihumi Shioda, Masayuki Mishima |
Fuji Gotemba Res. Labs., Chugai Pharmaceutical Co., Ltd., Gotemba, Japan |
| Helper T-cell proliferation assay to measure T-cell response to various antibody pharmaceuticals |
Chiyomi Kubo, Marie Hayakawa, Shunsuke Ito, Taichi Kuramochi, Yoshika Iwata, Akifumi Shioda, Toshiko Hara, Tomoaki Inoue, Masayuki Mishima |
Chugai Pharmaceutical CO., LTD. Fuji Gotemba Research Labs. |
| Risk assessment of cytokine release syndrome using human peripheral blood cells in vitro |
Yoshika Iwata (1), Chiyomi Kubo (1), Marie Hayakawa (1), Shunsuke Ito (1), Toshiko Hara (1), Akifumi Shioda (1), Tomoaki Inoue (1), Masayuki Mishima (1), Manigold Tobias (2), Hinton Heather (2), Kropshofer Harald (2) |
(1) Safety Assessment Dept., Fuji Gotemba Res. Labs., Chugai Pharmaceutical Co., Ltd., Gotemba, Japan, (2) Immunosafety, Non-clinical Safety, F Hofmann La-Roche Ltd, Basel, Switzerland |
| Sensitization study by quantitative structure-activity relationships (QSAR) |
Kazuhiro Sato, Yukinori Kusaka |
Department of Environmental Health, School of Medicine, University of Fukui, Fukui, Japan |
| Development of animal model represent exacerbation of childhood allergic dermatitis by |
Katsunori Yamaura, Seri Akiyama, Manabu Oda, Eriko Suwa, Koichi Ueno |
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University |
| STAT5 is activated by formaldehyde inhalation during pregnancy and infancy. |
Yasuhiro Yoshida (1), Ning Ding (1), Naoki Kunugita (2) |
(1) Department of Immunology and Parasitology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, (2) National Institute of Public Health, Wako, Japan |
| Effects of oral exposure to γ-benzene hexachloride during childhood in allergic airway inflammation |
Rie Yanagisawa, Eiko Koike, Hirohisa Takano |
National Institute for Environmental Studies, Environmental Health Sciences Division, Tsukuba, Japan |
| β-carotene intake inhibits oral sensitization and affects intestinal mucosal immunity |
Hiroshi Akiyama (1), Hideki Matsuoka (1), Kozue Sakata (1), Rika Nakamura (1), Shingo Takahashi (2), Takahiro Inakuma (2), Mamoru Totsuka (3), Reiko Teshima (3) |
(1) National Institute of Health Sciences, Tokyo, Japan, (2) Research Institute, KAGOME CO., LTD., Nasushiobara-chi, Japan, (3) The University of Tokyo, Tokyo, Japan |
| Histological Features and Airway Hyperresponsiveness in Polycyclic Aromatic Hydrocarbons Exacerbated Allergic Reaction in BALB/c mice |
Ryoji Hirota (1), Yumei Kang (2), Hiroyuki Nakamura (3), Narufumi Suganuma (1), Katsutoshi Sakurai (2) |
(1) Department of Environmental Medicine, Kochi Medical School, Nankoku, Japan, (2) Laboratory of Soil Environmental Science, Kochi University, (3) Kanazawa University Graduate School of Medical Science |
| Cytokines and tryptophan metabolites changes in mood disorders: Genetic and biochemical aspects |
Aye Mu Myint (1), Matthias Rothermundt (2), Michael Riedel (1), Markus Schwarz (1), Stephan Claes (3) |
(1) PNI Laboratory, Psychiatric Hospital, Ludwig-Maximilians University, Munich, Germany, (2) Psychiatric Hospital, University of Muenster, Muenster, Germany, (3( Psychiatric Hospital, Katholic University of Leuven, Leuven, Belgium |
| Poster Presentations |
| Prior exposure to organophosphorus and organochlorine compounds increases the allergic potential of chemical allergens |
Tomoki Fukuyama, Yukari Tajima, Hideo Ueda, Koichi Hayashi, Yasufumi Shutoh, Tadashi Kosaka, Takanori Harada |
The Institute of Environmental Toxicology, Toxicology Division, Ibaraki, Japan |
| The comparison of immunological effects of Chrysotile and Crocidolite asbestos fibers |
Takemi Otsuki, Megumi Maeda, Shoko Yamamoto, Hiroaki Hayashi, Naoko Kumagai, Yasumitsu Nishimura |
Department of Hygiene, Kawasaki Medical School, Kurashiki, Japan |
| Effect of diesel exhaust exposure on allergic reactions in the rat endometriosis model |
Masakazu Umezawa (1,2,3), Chika Sakata (1), Masako Tabata (1), Naomi Tanaka (1), Sayaka Kudo (1), Yumi Saito (1), Tomomi Ihara (2), Masao Sugamata (2), Ken Takeda (1,3) |
(1) Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda-city, Chiba, Japan, (2) Department of Pathology, Tochigi Institute of Clinical Pathology, Nogi-town, Chiba, Japan , (3) Research Center for Health Sciences of Nanoparticles, Research Institute for Science and Technology, Tokyo University of Science, Noda-city, Chiba, Japan |
| Effect of postnatal exposure to low-level toluene with peptidoglycan on the development of Th1/Th2 balance in mice |
Shoji Yamamoto, Tin-Tin Win-Shwe, Daisuke Nakajima, Hidekazu Fujimaki |
Research Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Japan |
| Murine oral food allergy model: Analysis of T cell subpopulations in mucosal lymphoid tissues |
Tomoko Shindo (1), Terumi Katori (1), Yukiko Kanazawa (2), Motoyasu Ohsawa (1), Kohichi Kojima (1), Reiko Teshima (3) |
(1) Hatano Research Institute, Food and Drug Safety Center, Hadano, Japan, (2) Pharmaceuticals and Medical Devices Agency, Tokyo, Japan, (3) National Institute of Health Sciences, Tokyo, Japan |
| Mast cells express hormone receptors, but treatment with estrogen exerts no detectable influence on mast cell secretions |
Shinji Takeuchi (1,2)，Morris Katherine (2)，St. Laurent Chris (2)，Moon Tae Chul (2)，吉村剛(2)，Sekar Yokananth (2)，Hiroyuki Kojima (1)，Befus Dean (2) |
(1) Hokkaido Institute of Public Health, Sapporo, Japan, (2) University of Alberta, Edmonton, Canada |
| The effect of the maternal consumption of lactic acid bacteria during pregnant and lactating periods on their pregnancy and offspring in mice |
Gaku Wagai, Kazuhiko Yoshizawa, Toshihide Kobayashi, Ikuo Kato, Kazumi Uchida |
Yakult Central Institute for Microbiological Research |
| A comparative study of Slc: WistarHannover/Rcc rats and Slc: SD rats onimmunotoxicological characteristics |
Yoshito Ohnuma, Yasuyuki Maeda |
Department of Life & Health Sciences, Teikyo University of Science, Yomanashi, Japan |
| The alterations in the subsets of splenic lymphocytes among the F1 rats exposed to tributyltin via the placenta and their dams’ milk |
Masashi Tsunoda (1), Takamasa Kido (1), Ryutaro Ikeuchi (1), Takaya Kaido (1), Mayuko Hosokawa (1,2), Chiemi Sugaya (1), Yuichiro Kudo (1), Koichi Hayashi (3), Tadashi Kosaka (3), Yuki Takeuchi (4), Tomoko Tashiro (4), Yoshiharu Aizawa (1) |
(1) Department of Preventive Medicine and Public Health, Kitasato University School of Medicine, Sagamihara, Japan , (2) Department of Epidemiology and Environmetal Health, Juntendo University School of Medicine , (3) The Institute of Environmental Toxicology , (4) Aoyama Gakuin University School of Science and Engineering |
| The detection of immuno-suppressive effects of DPH or MXC in female mice using Plaque-forming cell (PFC) assay |
Koichi Hayashi, Tomoki Fukuyama, Yukari Tajima, Yukiko Kashimoto, Yasufumi Shutoh, Hideo Ueda, Tadashi Kosaka |
The Institute of Environmental Toxicology |
| Cross-reactivity analysis of allergens revealed by EXiLE test |
Ryosuke Nakamura (1), Masakazu Higuchi (1), Rika Nakamura (1), Yasuto Kondo (2), Atsuo Urisu (3), Reiko Teshima (1) |
(1) Div. Novel Foods Immunochem., Natl. Inst. Health Sci., Tokyo, Japan, (2) Dept. Pediatrics, Fujita Health Univ. Sch. Med., Toyoake, Aichi, Japan, (3) Dept. Pediatrics, The Second Teaching Hospital of Fujita Health Univ., Aichi, Japan |
| Associations between HLA alleles and Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients (Third report) |
Emiko Sugiyama (1,2), Nahoko Kaniwa (1,2), Masahiro Tohkin (1,2), Kouichi Kurose (1,2), Ryuichi Hasegawa (2), Kayoko Matsunaga (2), Yukitoshi Takahashi (2), Hirokazu Furuya (2), Masaaki Muramatsu (2), Chie Sotozono (2), Shigeru Kinoshita (2), Michiko Aihara (2), Zenro Ikezawa (2), Yoshiro Saito (1,2) |
(1) Division of Medicinal of Safety Science, National Institute of Health Sciences, Tokyo, Japan, (2) JSCAR Research Group |
| Immunotoxicity evaluation in rats using T-cell independent antibody response |
Shiho Ito, Hiroyuki Hattori, Ryota Kawai, Satomi Komatsu, Keiko Muramatsu, Masae Yagi, Takuya Matsuyama, Tadashi Furukawa, Atsushi Sanbuissho |
Medicinal Safety Research Laboratories, Daiichi Sankyo Co., LTD., Shizuoka, Japan |
| Accuracy of LLNA: BrdU-ELISA to detect skin sensitization potential of chemicals |
Masafumi Horiuchi (1), Hideki Miyaura (1), Naoaki Yakata (1), Masahiro Takeyoshi (1), Naomi Kawazu (2), Masanori Taruki (2), Nobuhiko Higashibara (2) |
(1) Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute, Japan, (2) Hita Laboratory, Chemicals Evaluation and Research Institute, Japan |
| The Comparison of testing Conditions for T cell Dependent Antibody Reaction in Rats |
Hiroaki Oka, Mitsuhiro Fujieda, Hiroko Hitotsumachi, Yasuhide Kouchi |
Tokushima Research Center, Taiho pharmaceutical Co., Ltd., Japan |
| Four Week Repeated Dose Oral Immunotoxicity Study of Cyclophosphamide and Cyclosporin A in Rats |
Makoto Tsunemi, Hideki Tokudome, Takayuki Okamura, Hideki Harada, Yasuyuki Ohnishi, Hideaki Hiratsuka |
Safety Assessment Department, Mitsubishi Chemical Medience Corporation, Kashima, Japan |
| A New In Vitro Assay System for Assessment of Food Allergenicity (2) Evaluation of Proteins Digested In Vitro |
Terumi Katori (1), Tomoko Shindo (1), Motoyasu Ohsawa (1), Kohichi Kojima (1), Reiko Teshima (2) |
(1) Hatano Research Institute, Food and Drug Safety Center, Hadano, Japan, (2) National Institute of Health Sciences, Tokyo, Japan |
| Oral Presentations (Students' Session) |
| Change in expression pattern of human β defensins in mouse tracheal epithelium induced by toluene exposure |
Seiko Takeda (1), Tomoichirou Yamaai (2), Nobuyoshi Mizukawa (1), Yoshihiro Kaneda (1), Seiji Iida (1) |
(1) Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan., (2) Department of Oral Function and Anatomy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan |
| Enhancement of proliferation of splenocytes induced by fullerene nanoparticles instillation |
Ning Ding (1), Naoki Kunugita (2), Takamichi Ichinose (3), Yuan Song (1), Keiichi Arashidani (4), Yasuhiro Yoshida (1) |
(1) Department of Immunology and Parasitology, UOEH, (2) National Institute of Public Health, (3) Oita University of Nursing and Health Sciences, (4) School of Health Sciences, UOEH |
| Mechanism of the suppression of lymphocyte proliferation through an increase in p130 by inorganic arsenic |
Kazuyuki Okamura (1,2), Daisuke Miki (1,2), Keiko Nohara (1,2) |
(1) Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan, (29 Graduate School of Life and Environmental Sciences, Tsukuba University, Tsukuba, Japan |
| The mechanism for regulating the interleukin-6 in exposure to manganese |
Masashi Asao, Daigo Sumi, Seiichiro Himeno |
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan |
| Luncheon Seminar |
| Impact of the addendum to ICH S6 on the usage of tissue cross-reactivity studies in the pre-clinical development of antibody-based biopharmaceuticals |
Curtis Chan |
Special Pathology Services, Charles River Laboratories, Preclinical Services, USA |
| Therapeutic monoclonal antibodies - Predicting antibody-mediated cytokine release |
Christopher Kirton |
Experimental Biology, Huntingdon Life Sciences UK |
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