The 13th Annual Meeting of JSIT September 14-15, 2006, Kurashiki, Japan Keynote Lecture Pathophysiological development and immunotoxicology: what we have found from research related to silica and silicate such as asbestos Takemi Otsuki Department of Hygiene, Kawasaki Medical School Special Lecture 1 Immunotoxicology of Berylium lung disease Lee S. Newman University of Colorado at Denver and Health Services Center, USA Special Lecture 2 Models and mechanisms of chemical respiratory allergy: Not all allergens are equal Jean F. Regal (1), Amy L. Greene (1), Ronald R Regal (2), Mark Rutherford (3) (1) Biochemistry & Molecular Biology, University of Minnesota Medical School, Duluth, MN, USA, (2) Mathematics & Statistics, University of Minnesota, Duluth, MN, USA, (3) Veterinary & Biomedical Sciences, University of Minnesota, St. Paul, MN, USA Special Lecture 3 Interaction between therapeutics and the immune system: Case studies Khalil Hayssam Department of Immunology, Charles River Laboratories Preclinical Services, Montreal, Canada Invited Lecture 1 Inflammation and environmental factors Hiroyuki Takano Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan Invited Lecture 2 Sick house syndrome research 2006 Kou Sakabe Department of Public Health and Molecular Toxicology, Kitasato University School of Pharmaceutical Sciences, Environmental Medical Center, The Kitasato Institute, Tokyo, Japan Symposium: Fibrous and nanomaterials and immunotoxicological research Organizer Seishiro Hirano Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan Yasumitsu Nishimura Department of Hygiene, Kawasaki Medical School, Kurashiki, Japan Factors in hazard evaluation of fibrous materials Yasuo Morimoto Department of Occupational Pneumology, Institute of Industrial Ecological Science, University of Occupational and Environmental Health, Kitakyushu, Japan Functional alteration of natural killer Cells exposed to asbestos for a long period Yasumitsu Nishimura (1), Yoshie Miura (2), Megumi Maeda (1), Hiroaki Hayashi (1), Takemi Otsuki (1) (1) Department of Hygiene, Kawasaki Medical School, Kurashiki, Japan, (2)Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, USA Transport of nanoparticles through aleveolo-capillary barrier Akiko Furuyama, Sanae Kanno, Seishiro Hirano Research Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Japan Nanoparticles as drug delivery system: Issues and perspectives Masahiro Murakami Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan Workshop A guideline to immunotoxicity studies of human pharmaceutics Organizer Jun-ichi Sawada Division of Biochemistry and Immunochemistry, The National Institute of Health Science, Tokyo, Japan Naohisa Tsutsui Toxicology Laboratories, Pharmaceuticals Research Department, Mistubishi Pharma Corporation, Chiba, Japan ICH (International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use) S8 Immunotoxicity guideline Jun-ichi Sawada Division of Biochemistry and Immunochemistry, The National Institute of Health Science, Tokyo, Japan Pathology of lymph nodes and Peyer's patches Toshio Imai (1), Jiro Sonoda (2), Hiroshi Maeda (3), Shigeru Hisada (1) (1) Division of Pathology, National Institute of Health Science, Tokyo, Japan, (2) Drug Safety Research Laboratories, Eisai Co., Ltd., Ibaragi, Japan, (3) Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories Co., Ltd., Tokyo, Japan, (4) Safety Research Department, ASKA Pharmaceutical Co., Ltd., Kanagawa, Japan Interpretation of stress-related changes Shigeru Hisada Safety Research Department, ASKA Pharmaceutical Co., Ltd., Kawasaki, Japan The Immunotoxicology inter-laboratory project (IILP): The Validation of a T cell-dependent antibody response (TDAR) using keyhole limpet hemocyanin (KLH) in rats Andre H Penninks TNO Quality of Life Product Manager, Experimental Immunology, AJ Zeist, The Netherlands), gave his lecture in the name of the IILP group of investigators Q & A format lecture about the "Explanation of ICH S8 guideline Osamu Fueki Office of New Drug I, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan Naohisa Tsutsui Toxicology Laboratories, Pharmaceuticals Research Department, Mistubishi Pharma Corporation, Chiba, Japan General Oral Presentation Comparison of the ELISA versus PFC assay for detection of T cell dependent antibody response in 6 strain rats Ryota Kawai, Tetsuo Aida, Motoko Ajioka, Masae Yagi, Satomi Komatsu, Tsutomu Kimura, Tadashi Furukawa, Sunao Manabe edicinal Safety Research Laboratories, Sankyo Co., Ltd., Japan Relationship between IL-6 and anti-oxidant proteins produced in rats, i.p. treated with carbon tetrachloride Yosuke Ochiai, Kenich Onishi, Kenzaburo Yamadi, Toshiyuki Chikuma, Hiroshi Hojo Department of Hygienic Chemistry, Showa Pharmaceutical University, Tokyo, Japan Relation of chemical structure and induction activity of apoptosis in an organotin's sight Kenichi Tomiyama, Akiko Yamaguchi, Yurie Sayama, takao Kuriyama, Yasuaki Arakawa Department of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan The differences between types of murine astrocyte cell lines for the toxic effects of dobutyl, octyl acid and poly-L-lactides Masashi Tsunoda (1), Takayuki Haino (2), Kyoko Ito (1), Yoko Inoue (1), Takeo Miki (1), Yuichiro Kudo (1), Toshihiko Satoh (1), Yoshiharu Aizawa (1), Toshie Tsuchiya (3) (1) Department of Preventive Medicine and Public Health, Kitasato University School of Medicine, Sagamihara, Japan, (2) Department of Obsterics and Gynecology, Jikei University School of Medicine, Tokyo, Japan, (3) Division of Medical Devices, National Institute of Health Sciences, Tokyo, Japan Methoxychlor induces thymic apoptosis in vivo in mice Tomoki Fukuyama, Yukari Tajima, Koichi Hayashi, Atsuko Haishima, Hideaki Fujie, Tsutomu, Matsumoto, Yutaka Hayashi, Hideo Ueda, Yasufumi Shutoh, Tadashi Kosaka, Takanori Harada Laboratory of Immunotoxicology and Acute Toxicology, Toxicology Division, The Institute of Environmental Toxicology, Ibaragi, Japan Analysis on Immune reaction in T-cell specific constotutively-active AhR mutant transgenic mice to clarify the role of activated AhR in T cells Keiko Nohjara (1), Kana Ao (1), Yoshimi Miyamoto (1), Tomohiro Ito (1), Kaoru Inouye (1), Xiaoqing Pan (1), Hozumi Motohashi (2), Masayuki Yamamoto (2), Chiharu Tohyama (3) (1) Environmental Health Scieneces Division, National Institute for Environmental Studies, Tsukuba, Japan, (2) TARA Center, University of Tsukuba, (3) CDBIM, University of Tokyo Screening of the novel anti-allergic peptide in milk protein Takeaki Okamoto, Sayuri Ono, Yohsuke Minatogawa Department of Biochemistry, Kawasaki Medical School, Okayama, Japan Effects of antithyroids on the debeloping immune system of the rat Ryosuke Nakamura (1), Reiko Teshima (1), Akiko Hachisuga (1), Kayoko Takagi (1), Gye-Hyeong Woo (2), Makoto Shibutani (2), Jun-Ichi Sawada (1) (1) Div. Biochem. Immunochem., (2) Div. Pathol., Natl. Inst. Health Sci., Tokyo, Japan Effects of NSAIDs administered during late-gestation on the development of immune system in rat pups Kiyoshi Kushima, Keiko Oda, Shozo Sakuma, Michio Fujiwara Drug Safety Research Laboratories, Astellas Pharma, Osaka, Japan In vitro screening for drug-induced anaphylactoid reaction Takako Hamano, Taizou Tomari, Saori Okada, Naohisa Tsutsui Toxicology Laboratory, Pharmaceutics Research Division, Mitsubishi Pharma Corporation, Japan Murine food allergy model with oral sensitization and oral challenge (5) Tomoko Shindo (1), Yukiko Kanazawa (1), Mami Furuya (1), Yoshiyuki Tazuru (1), Kohichi Kojima (1), Reiko Teshima (2) (1) Hatano Research Institute, Food and Drug Safety Center, Kanagawa, Japan, (2) National Instoitute of Health Science, Tokyo, Japan Suppression of IL-1-induced MCP-1 release by environmetal chemicals Kunihiro Akimaru, Ryoji Hirota, Takeshi Nakamura, Da-Chuan Zhang, Hiroyuki Nakamura Environmental Medicine, Kochi Medical School, University of Kochi, Nankoku, Japan Analysis of pathological related gene expression on lymphocytes from patients with asbestos-induced disxeases Megumi Maeda (1), Yoshie Miura (1), Yasumitsu Nishimura (1), Hiroaki Hayashi (1), Maolong Dong (1), Ayuko Uesaka (2), Kozo Kuribayashi (2), Takashi Nakano (2), Takumi Kishimoto (3), Takemi Otsuki (1) (1) Department of Hygiene, Kawasaki Medical School, Kurashiki, Japan, (2) Department of Respiratory Medicine, Hyogo College of Medicien, Nishinomiya, Hyogo, Japan, (3) Okayama Rosai Hospital, Okayama, Japan Regulation of dendritic cell functions by neuropeptide CGRO via RAMP1/CL receptors Kazutake Tsujikawa, Tomomi Shigeno, Yusuke Ohgitani, Emi Hirayama, So-Ichiro Fukuda, Hiroshi Yamamoto Department of Immunology, Graduate School of Pharmaceutical Science, Osaka University, Osaka, Japan Immunocharacterization of arsenite-induced human macrophages (As-Mp) Teruaki Sakurai, Seiichiro Himeno Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Scieneces, Tokushima Bunri University, Tokushima, Japan Inhibitory activities of squamous cell carcinoma antigens on extrinsic cysteine proteases Yoko Tanaka (1), Sachiko Kanaji (1), Yasuhisa Sakata (1), Kiyonari Masumoto (1), Kohei Takeshita (1), Kazuhiko Arima (1), John P. Dalton (2), James H. McKerrow (3), Graham H. Coombs (4), Kenzi Izuhara (1) (1) Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan, (2) Instotute for the Biotechnology of Infectious Diseases, University of Technology Sydney, Australia, (3) Sandler Center, UCSF, San Francisco, CA, USA, (4) Division of Infection and Immunology, Instotute of Biomedical and Life Sciences, Wellcome Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, University of Glasgow, UK General Poster Presentation Anti-KHL IgG antibody response in rat for immunotoxocity evaluation Koichi Hayashi, Tadashi Kosaka, Tomoki Fukuyama, Yukari Tajima, Hideo Ueda, Takanori Harada The Instotute of Environmental Toxicology, Ibaragi, Japan Evaluation of skinsensitizing potential on chromated cooper arsenate (CCA) used as a wood preservative Hideo Ueda, Tomoki Fukuyama, Koichi Hayashi, Yukari Tajima, Hideaki Fujie, Yutaka Hayashi, Atuko Haishima, Yasufumi Shutoh, Tadashi Kosaka, Takanori Harada Toxicology Division, The Instotute of Environmental Toxicology, Ibaragi, Japan Changes in gene expression in the lungs of paraquat-intoxicated mouse model Masafumi Tomita (1), Hironobu Katsuyama (2), Yasumitsu Nishimura (3), Yoshie Miura (3), Yoko Watanabe (4), Kazuo Hidaka (4), Takemi Otsuki (1) (1) Department of Medical Toxicology, (2) Department of Public Health, (3) Department of Hygiene, (4) Department of Biochemistry, Kawasaki Medical School, Kurashiki, Japan Analysis of dioxin-regulated genes in DN thymocytes using microarray Tomohiko Ito, Keiko Nohara Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan Effect of DBDE on the immune system in the developing postnatal rats Reiko Teshima (1), Ryosuke Nakamura (1), Rika Nakamura (1), Akiko Hachisuka (1), Jun-Ichi Sawada (1), Makoto Shibutani (2) (1) Division of Biochemistry and Immunochemistry, (2) Division of Pathology, National Institute of Health Science, Tokyo, Japan Effects of dexamethasone on maternal and offspring immune system exposed during gestational or lactation period in rats Motoyuki Kawai, Masafumi Nagata, Misa Yamai, Masahiro Hirashiba, Susumu Kanamori, Atsuko Hishikawa, Kazuichi Nakamura Developmental research Laboratories, Shionogi & Co., Ltd., Osaka, Japan Evaluation of sensitization potential of drugs using secondary popliteal lymph node assay Akihiko Hisatomi, Kiyoshi Kushima, Shozo Sakuma, Michio Fujiwara Drug Safety Research Laboratories, Astellas Pharma Inc., Osaka, Japan Effect of butylhydroxytokuene on allergic reactions Kouya Yamaki, Shin Yoshino Department of Pharmacology, Kobe Pharmaceutical University, Kobe, Japan Suppressive effects on hypersensitivity by dietary restriction in isocyanate sensitized mice Nobuhiro Nishio (1), Katsuyasu Kouda (2), Hirao Kouno (3), Hiroyasu Ishihara (3), Harunobu Nakamura (4), Tastuya Takeshita (1) (1) Department of Public Health, Wakayama Medical University, Wakayama, Japan, (2) Department of Public Health, Kinki University, Osaka, Japan, (3) Department of Hygiene, Kansai Medical University, Osaka, Japan, (4) Development Science, Kobe University, Hyogo, Japan 17beta-estradiol enhamces IL-18 expression in mouse contact hypersensitivity Fumitoshi Sakazaki, Masahiro Fujiyama, Hitoshi Ueno, Katsuhiko Nakamura Faculty of Pharmaceutical Sciences, Setsunan University, HIrakata, Osaka, Japan Investigation of analytical method for lymphocyte subset in rat blood and organ samples Daisuke Mukai, Maki Shibata, Maki Makita, Eiji Maki Biosafety Research Center, Foods, Drugs and Pesticides, Shizuoka, Japan The Colormetric assay by cell counting kit-8 for rat peripheral blood and splenic lymphocyte blastgenesis Seiji Shibata, Mitsui Isobe, Shigeru Hisada Safety Research Department, ASAKA Pharmaceutical Co., Ltd., Kawasaki, Japan Analysis of regulatory T cells in silicosis patients Hiroaki Hayashi (1), Yoshie Miura (1), Fuminori Hyodoh (2), Yasumitsu Nishimura (19< Megumi Maeda (1), Maolong Dong (1), Masayasu Kusaka (3), Hironobu Katsuyama (4), Masafumi Tomita (5), Takemi Otsuki (1) (1) Department of Hygiene, (4) Department of Publiuc Health, (5) Department of Medical Toxicology, Kawasaki Medical School, Kurashiki, Japan, (2) Department of Nursing, Kawasaki College of Allied Health Professions, Kurashiki, Japan, (3) Department of Internal Medicine, Kuraka Hospital, Bizen, Japan Luncheon seminar 1 Immunotoxicology assessment Lawrence Jacob Molecular Biology and Immunology, Central Laboratory, Charles River Laboratories Preclinical Services, Edinburgh, Scotland, UK Luncheon seminar 2 In vitro and in vivo prediction of monoclonal antibody cytokine release syndrome in man Mark Wing Huntington Life Science Ltd., UK